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Dynamic Restriction of the Src-family Kinase Fgr Enhances ATP-site Inhibitor Potency and Reduces Leukemogenic Potential

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Title
  • Dynamic Restriction of the Src-family Kinase Fgr Enhances ATP-site Inhibitor Potency and Reduces Leukemogenic Potential
Last modified
  • 04/03/2026
Creator
Abstract
  • Development of acute myeloid leukemia (AML) is often associated with overexpression of non-receptor tyrosine kinases, including the three Src-family kinase (SFK) members Hck, Lyn and Fgr. SFK inhibitors with significant anti-AML efficacy include the pyrrolopyrimidine A-419259 and the N-phenylbenzamide TL02-59. Previously solved x-ray crystal str...
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Type
Degree discipline
  • Molecular Biophysics and Structural Biology
Degree grantor
  • University of Pittsburgh School of Medicine
Degree level
  • doctoral
Degree name
  • Doctor of Philosophy
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MLA citation style (9th ed.)

Giancarlo Gonzalez-Areizaga. Dynamic Restriction of the Src-family Kinase Fgr Enhances Atp-site Inhibitor Potency and Reduces Leukemogenic Potential. d-scholarship.pitt.edu/concern/etds/bf54b348-26ef-46b0-9b50-74e003e3e0fe.

APA citation style (7th ed.)

G. Gonzalez-areizaga. Dynamic Restriction of the Src-family Kinase Fgr Enhances ATP-site Inhibitor Potency and Reduces Leukemogenic Potential. https://d-scholarship.pitt.edu/concern/etds/bf54b348-26ef-46b0-9b50-74e003e3e0fe

Chicago citation style (CMOS 17, author-date)

Giancarlo Gonzalez-Areizaga. Dynamic Restriction of the Src-Family Kinase Fgr Enhances Atp-Site Inhibitor Potency and Reduces Leukemogenic Potential. https://d-scholarship.pitt.edu/concern/etds/bf54b348-26ef-46b0-9b50-74e003e3e0fe.

Note: These citations are programmatically generated and may be incomplete.

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