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24-hour movement behaviors and cognitive performance in older adults: a compositional and isotemporal reallocation analysis

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69 pages

Title
  • 24-hour movement behaviors and cognitive performance in older adults: a compositional and isotemporal reallocation analysis
Date modified
  • 11/07/2025
Creator
Abstract
  • Background: Previous research found beneficial health effects of 24-hour movement behaviors (sleep, sedentary activity, light-intensity physical activity (LIPA), and moderate-to-vigorous intensity physical activity (MVPA)) on cognition, however, these studies analyzed the relationship between these behaviors and cognition in isolation, which could lead to bias in the interpretation since the behaviors are inter-related. In this study, we aimed to be the first to disentangle the relationship between objectively measured 24-hour movement behaviors and cognitive performance among older men using a compositional data analysis approach. Methods: The study was a cross-sectional secondary data analysis of the Osteoporotic Fractures in Men Study (MrOS), with 2,981 men (median age: 78 years) enrolled from visit 3. 24-hour movement behaviors were measured by wearing the activity monitor (SenseWear® Pro3 Armband) on their right arm for seven days. Cognitive function was assessed by the Modified Mini-Mental Status (3MS) examination and Part B of the Trail Making Test (Trails B test) tools. Multiple linear regressions were used to test the relationship between the 24-hour movement behaviors and cognition performance using the isotemporal substitution regression model (ISM) and compositional data analysis (CoDA) approaches. Results: In ISM, replacing 30 min/day of sedentary activity with sleep was deleteriously associated with poorer global cognitive function (β= 0.010; 95% CI= 0.000, 0.020) and poorer executive cognitive function (β= 0.009; 95% CI= 0.003, 0.014). Replacing 30 min/day of LIPA with sleep (β= 0.046; 95% CI= 0.027, 0.065), sedentary activity (β= 0.038; 95% CI= 0.019, 0.057), and MVPA (β= 0.041; 95% CI= 0.015, 0.068) resulted in poorer executive cognitive function. In CoDA, reallocating 30 min/d from sedentary activity to sleep were associated with poorer global cognitive function (effect size (ES), ES=0.007; 95% CI=0.038, 0.063) and worse executive cognitive function (ES=0.005; 95% CI=0.004, 0.006), but reallocating 30 min/d from sedentary activity to LIPA (ES= -0.008; 95% CI= -0.019, -0.003) and MVPA (ES= -0.011; 95% CI= -0.012, -0.005) was beneficially associated with predicted global cognitive function. Conclusions: Our results suggest an integrated role of 24-hour movement behaviors on cognition, and suggest that physical activity, particularly LIPA, plays an important role in delaying cognitive decline among older adults.
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Date created
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Language
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Degree discipline
  • Epidemiology
Degree grantor
  • University of Pittsburgh
Degree level
  • Masters
Degree name
  • Master of Science
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MLA citation style (9th ed.)

Shi, Hui. 24-hour Movement Behaviors and Cognitive Performance In Older Adults: a Compositional and Isotemporal Reallocation Analysis. . 2023. d-scholarship.pitt.edu/concern/etds/cfb59b48-4d81-4e34-be24-65850499b73d.

APA citation style (7th ed.)

S. Hui. (2023). 24-hour movement behaviors and cognitive performance in older adults: a compositional and isotemporal reallocation analysis. https://d-scholarship.pitt.edu/concern/etds/cfb59b48-4d81-4e34-be24-65850499b73d

Chicago citation style (CMOS 17, author-date)

Shi, Hui. 24-Hour Movement Behaviors and Cognitive Performance In Older Adults: a Compositional and Isotemporal Reallocation Analysis. 2023. https://d-scholarship.pitt.edu/concern/etds/cfb59b48-4d81-4e34-be24-65850499b73d.

Note: These citations are programmatically generated and may be incomplete.

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