Dugan, VG and Chen, R and Spiro, DJ and Sengamalay, N and Zaborsky, J and Ghedin, E and Nolting, J and Swayne, DE and Runstadler, JA and Happ, GM and Senne, DA and Wang, R and Slemons, RD and Holmes, EC and Taubenberger, JK
(2008)
The evolutionary genetics and emergence of avian influenza viruses in wild birds.
PLoS Pathogens, 4 (5).
ISSN 1553-7366
Abstract
We surveyed the genetic diversity among avian influenza virus (AIV) in wild birds, comprising 167 complete viral genomes from 14 bird species sampled in four locations across the United States. These isolates represented 29 type A influenza virus hemagglutinin (HA) and neuraminidase (NA) subtype combinations, with up to 26% of isolates showing evidence of mixed subtype infection. Through a phylogenetic analysis of the largest data set of AIV genomes compiled to date, we were able to document a remarkably high rate of genome reassortment, with no clear pattern of gene segment association and occasional inter-hemisphere gene segment migration and reassortment. From this, we propose that AIV in wild birds forms transient "genome constellations," continually reshuffled by reassortment, in contrast to the spread of a limited number of stable genome constellations that characterizes the evolution of mammalian-adapted influenza A viruses.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID |
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Dugan, VG | | | | Chen, R | | | | Spiro, DJ | | | | Sengamalay, N | | | | Zaborsky, J | | | | Ghedin, E | elg21@pitt.edu | ELG21 | | Nolting, J | | | | Swayne, DE | | | | Runstadler, JA | | | | Happ, GM | | | | Senne, DA | | | | Wang, R | | | | Slemons, RD | | | | Holmes, EC | | | | Taubenberger, JK | | | |
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Contributors: |
Contribution | Contributors Name | Email | Pitt Username | ORCID |
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Editor | Perez, Daniel R. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED |
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Date: |
1 May 2008 |
Date Type: |
Publication |
Journal or Publication Title: |
PLoS Pathogens |
Volume: |
4 |
Number: |
5 |
DOI or Unique Handle: |
10.1371/journal.ppat.1000076 |
Refereed: |
Yes |
ISSN: |
1553-7366 |
PubMed ID: |
18516303 |
Date Deposited: |
18 Jul 2012 20:29 |
Last Modified: |
04 Feb 2019 16:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/12979 |
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