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Association of single nucleotide polymorphisms of the MRC1 gene and dengue fever in a Brazilian population

Cathcart, Erin (2013) Association of single nucleotide polymorphisms of the MRC1 gene and dengue fever in a Brazilian population. Master Essay, University of Pittsburgh.

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Abstract

Dengue virus infections are a major public health burden worldwide, with an estimated 50 million cases annually. Research has demonstrated the ability of the virus to infect macrophages by binding to the macrophage mannose receptor; however, this mechanism is not completely understood. The gene coding for the receptor, MRC1, has many single nucleotide polymorphisms (SNPs), and the objective of this study was to evaluate the association of two SNPs, rs2296414 and rs34039386, with dengue virus infection in a sample from Recife, Brazil. DNA was extracted from leukocytes purified from blood samples of patients and amplified using PCR. Genotypes were determined using either fluorescence polarization (rs2296414) or restriction digest (rs34039386). A statistically significant association between disease and sex, with females having an increased risk was found for both the rs2296414 and rs34039386 SNPs, OR=2.19 p


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Details

Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Cathcart, Erin
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
Committee Co-ChairFerrell, Robertrferrell@pitt.eduRFERRELLUNSPECIFIED
Committee Co-ChairMartinson, Jeremyjmartins@pitt.eduJMARTINSUNSPECIFIED
Committee MemberMarques, Ernesto T Amarques@pitt.eduMARQUESUNSPECIFIED
Committee MemberKammerer, Candacecmk3@pitt.eduCMK3UNSPECIFIED
Date: 19 April 2013
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Publisher: University of Pittsburgh
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Infectious Diseases and Microbiology
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Date Deposited: 11 May 2015 17:31
Last Modified: 09 Jul 2019 12:55
URI: http://d-scholarship.pitt.edu/id/eprint/19635

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