Association of single nucleotide polymorphisms of the MRC1 gene and dengue fever in a Brazilian population

Cathcart, Erin (2013) Association of single nucleotide polymorphisms of the MRC1 gene and dengue fever in a Brazilian population. Master Essay, University of Pittsburgh.

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Abstract

Dengue virus infections are a major public health burden worldwide, with an estimated 50 million cases annually. Research has demonstrated the ability of the virus to infect macrophages by binding to the macrophage mannose receptor; however, this mechanism is not completely understood. The gene coding for the receptor, MRC1, has many single nucleotide polymorphisms (SNPs), and the objective of this study was to evaluate the association of two SNPs, rs2296414 and rs34039386, with dengue virus infection in a sample from Recife, Brazil. DNA was extracted from leukocytes purified from blood samples of patients and amplified using PCR. Genotypes were determined using either fluorescence polarization (rs2296414) or restriction digest (rs34039386). A statistically significant association between disease and sex, with females having an increased risk was found for both the rs2296414 and rs34039386 SNPs, OR=2.19 p

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Details

Item Type:	Other Thesis, Dissertation, or Long Paper (Master Essay)
Status:	Unpublished
Creators/Authors:	Creators Email Pitt Username ORCID Cathcart, Erin
Contributors:	Contribution Contributors Name Email Pitt Username ORCID Committee Co-Chair Ferrell, Robert rferrell@pitt.edu RFERRELL UNSPECIFIED Committee Co-Chair Martinson, Jeremy jmartins@pitt.edu JMARTINS UNSPECIFIED Committee Member Marques, Ernesto T A marques@pitt.edu MARQUES UNSPECIFIED Committee Member Kammerer, Candace cmk3@pitt.edu CMK3 UNSPECIFIED
Date:	19 April 2013
Date Type:	Publication
Access Restriction:	No restriction; Release the ETD for access worldwide immediately.
Publisher:	University of Pittsburgh
Institution:	University of Pittsburgh
Schools and Programs:	School of Public Health > Infectious Diseases and Microbiology
Degree:	MPH - Master of Public Health
Thesis Type:	Master Essay
Refereed:	Yes
Date Deposited:	11 May 2015 17:31
Last Modified:	30 Sep 2023 11:55
URI:	http://d-scholarship.pitt.edu/id/eprint/19635

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