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The effect of L-arginine and L-citrulline on NOx production in primary human airway epithelial cells exposed to asymmetric dimethylarginine (ADMA)

Winnica, Daniel Efrain and Baffi, Cynthia Wilson and Wenzel, Sally E. and Holguin, Fernando (2014) The effect of L-arginine and L-citrulline on NOx production in primary human airway epithelial cells exposed to asymmetric dimethylarginine (ADMA). In: 8th International conference on the biology, chemistry and therapeutic application of Nitric Oxide (NO2014).

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Abstract

We determine: 1) whether the addition of asymmetric dimethylarginine (ADMA) reduces nitric oxide (NO)-related metabolites in primary airway epithelial cells under IL-13/ IFNγ stimulation, 2) supplementation of L-arginine/L-citrulline to cultures with high ADMA/iNOS expression is able to redirect iNOS towards NOx production. L-arginine and L-citrulline supplementation are able to increase the formation of NOx (nitrates + nitrates) in human airway epithelial cells, despite treatment with endogenous iNOS inhibitor ADMA. L-arginine and L-citrulline may have a therapeutic potential in diseases in which there is a defective production of NO.


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Details

Item Type: Conference or Workshop Item (Poster)
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Winnica, Daniel Efraindew23@pitt.eduDEW23
Baffi, Cynthia Wilson
Wenzel, Sally E.
Holguin, Fernandofeh9@pitt.eduFEH9
Date: 16 July 2014
Date Type: Publication
Journal or Publication Title: F1000 Research
Publisher: F1000 Research Ltd.
Event Title: 8th International conference on the biology, chemistry and therapeutic application of Nitric Oxide (NO2014)
Event Type: Conference
Schools and Programs: School of Medicine > Critical Care Medicine
School of Medicine > Medicine
Refereed: No
ISSN: 2046-1402
Official URL: https://f1000research.com/posters/1096220
Additional Information: Competing Interests: No competing interests were disclosed
Date Deposited: 22 Nov 2016 17:38
Last Modified: 14 Aug 2018 19:55
URI: http://d-scholarship.pitt.edu/id/eprint/30151

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