The effect of L-arginine and L-citrulline on NOx production in primary human airway epithelial cells exposed to asymmetric dimethylarginine (ADMA)

Winnica, Daniel Efrain and Baffi, Cynthia Wilson and Wenzel, Sally E and Holguin, Fernando (2014) The effect of L-arginine and L-citrulline on NOx production in primary human airway epithelial cells exposed to asymmetric dimethylarginine (ADMA). In: 8th International conference on the biology, chemistry and therapeutic application of Nitric Oxide (NO2014).

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Abstract

We determine: 1) whether the addition of asymmetric dimethylarginine (ADMA) reduces nitric oxide (NO)-related metabolites in primary airway epithelial cells under IL-13/ IFNγ stimulation, 2) supplementation of L-arginine/L-citrulline to cultures with high ADMA/iNOS expression is able to redirect iNOS towards NOx production. L-arginine and L-citrulline supplementation are able to increase the formation of NOx (nitrates + nitrates) in human airway epithelial cells, despite treatment with endogenous iNOS inhibitor ADMA. L-arginine and L-citrulline may have a therapeutic potential in diseases in which there is a defective production of NO.

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Details

Item Type:	Conference or Workshop Item (Poster)
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Winnica, Daniel Efrain dew23@pitt.edu DEW23 Baffi, Cynthia Wilson Wenzel, Sally E Holguin, Fernando feh9@pitt.edu FEH9
Date:	16 July 2014
Date Type:	Publication
Journal or Publication Title:	F1000 Research
Publisher:	F1000 Research Ltd.
Event Title:	8th International conference on the biology, chemistry and therapeutic application of Nitric Oxide (NO2014)
Event Type:	Conference
Schools and Programs:	School of Medicine > Critical Care Medicine School of Medicine > Medicine
Refereed:	No
ISSN:	2046-1402
Official URL:	https://f1000research.com/posters/1096220
Additional Information:	Competing Interests: No competing interests were disclosed
Date Deposited:	22 Nov 2016 17:38
Last Modified:	31 Jul 2020 19:12
URI:	http://d-scholarship.pitt.edu/id/eprint/30151

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