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Depression in Primary care: Interpersonal Counseling vs Selective serotonin reuptake inhibitors. The DEPICS Study. A multicenter randomized controlled trial. Rationale and design

Menchetti, M and Bortolotti, B and Rucci, P and Scocco, P and Bombi, A and Berardi, D and Affatati, V and Alberini, G and Baranzini, F and Bellino, S and Bellomo, A and Blasi, T and Bogetto, F and Bortolaso, P and Callegari, C and Carpiniello, B and Colombini, N and Contu, C and Croci, G and De Salvia, M and Diurni, M and Elisei, S and Ferretti, M and Fiore, P and Fusar-Poli, P and Iuso, S and Lacalamita, A and La Ferla, T and Lia, L and Luciano, CC and Magnani, M and Manganaro, D and Martinelli, V and Martino, I and Montaguti, MB and Nespeca, C and Petito, A and Pinna, F and Piselli, M and Politi, P and Quartesan, R and Rella, A and Restaino, F and Rigatelli, M and Sciarini, P and Simoni, E and Succui, M and Tedeschini, E and Todarello, O and Vender, S and Zaccagni, L and Zizza, M and Lullini, G and Pedrini, E and D'Onghia, A and Mazza, M and Papagni, S (2010) Depression in Primary care: Interpersonal Counseling vs Selective serotonin reuptake inhibitors. The DEPICS Study. A multicenter randomized controlled trial. Rationale and design. BMC Psychiatry, 10.

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Background: Depression is a frequently observed and disabling condition in primary care, mainly treated by Primary Care Physicians with antidepressant drugs. Psychological interventions are recommended as first-line treatment by the most authoritative international guidelines but few evidences are available on their efficacy and effectiveness for mild depression.Methods/Design: This multi-center randomized controlled trial was conducted in 9 Italian centres with the aim to compare the efficacy of Inter-Personal Counseling, a brief structured psychological intervention, to that of Selective Serotonin Reuptake Inhibitors. Patients with depressive symptoms referred by Primary Care Physicians to psychiatric consultation-liaison services were eligible for the study if they met the DSM-IV criteria for major depression, had a score ≥13 on the 21-item Hamilton Depression Rating Scale, and were at their first or second depressive episode. The primary outcome was remission of depressive symptoms at 2-months, defined as a HDRS score ≤ 7. Secondary outcome measures were improvement in global functioning and recurrence of depressive symptoms at 12-months. Patients who did not respond to Inter-Personal Counseling or Selective Serotonin Reuptake Inhibitors at 2-months received augmentation with the other treatment.Discussion: This trial addresses some of the shortcomings of existing trials targeting major depression in primary care by evaluating the comparative efficacy of a brief psychological intervention that could be easily disseminated, by including a sample of patients with mild/moderate depression and by using different outcome measures. © 2010 Menchetti et al; licensee BioMed Central Ltd.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Menchetti, M
Bortolotti, B
Rucci, P
Scocco, P
Bombi, A
Berardi, D
Affatati, V
Alberini, G
Baranzini, F
Bellino, S
Bellomo, A
Blasi, T
Bogetto, F
Bortolaso, P
Callegari, C
Carpiniello, B
Colombini, N
Contu, C
Croci, G
De Salvia, M
Diurni, M
Elisei, S
Ferretti, M
Fiore, P
Fusar-Poli, P
Iuso, S
Lacalamita, A
La Ferla, T
Lia, L
Luciano, CC
Magnani, M
Manganaro, D
Martinelli, V
Martino, I
Montaguti, MB
Nespeca, C
Petito, A
Pinna, F
Piselli, M
Politi, P
Quartesan, R
Rella, A
Restaino, F
Rigatelli, M
Sciarini, P
Simoni, E
Succui, M
Tedeschini, E
Todarello, O
Vender, S
Zaccagni, L
Zizza, M
Lullini, G
Pedrini, E
D'Onghia, A
Mazza, M
Papagni, S
Date: 25 November 2010
Date Type: Publication
Journal or Publication Title: BMC Psychiatry
Volume: 10
DOI or Unique Handle: 10.1186/1471-244x-10-97
Schools and Programs: School of Medicine > Medicine
School of Medicine > Psychiatry
Refereed: Yes
Date Deposited: 16 Nov 2016 16:06
Last Modified: 20 Dec 2018 00:55


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