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Effect of insulin on glucose metabolism in the dog after portacaval transposition

Starzl, Thomas E and Scanlan, William A and Thornton, Fred H and Wendel, Robert M and Stearn, Burton and Lazarus, Robert E and McAllister, William and Shoemaker, William C (1965) Effect of insulin on glucose metabolism in the dog after portacaval transposition. American Journal of Physiology-Legacy Content, 209 (1). 221 - 226. ISSN 0002-9513

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<jats:p> The effect of insulin on hepatic glucose metabolism was studied by a multiple-catheter technique in unanesthetized dogs with Eck fistula and with portacaval transposition. With the latter preparation, blood entering and leaving the liver was sampled from peripherally inserted catheters. In the unanesthetized Eck-fistula animals, insulin infusion produced a decrease in the hepatic glucose output. In the dogs with portacaval transposition, a constant infusion of insulin was given alternately by systemic and by intraportal routes. There was no significant difference between the effects of insulin administered by the two routes. During insulin infusion, glucose concentration differences across the liver were reduced, hepatic plasma flow was transiently elevated, and hepatic glucose output was decreased. After discontinuance of insulin, there was a transient rise of hepatic glucose output to above control values. </jats:p>


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Starzl, Thomas Etes11@pitt.eduTES11
Scanlan, William A
Thornton, Fred H
Wendel, Robert M
Stearn, Burton
Lazarus, Robert E
McAllister, William
Shoemaker, William C
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 July 1965
Date Type: Publication
Journal or Publication Title: American Journal of Physiology-Legacy Content
Volume: 209
Number: 1
Publisher: American Physiological Society
Page Range: 221 - 226
DOI or Unique Handle: 10.1152/ajplegacy.1965.209.1.221
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0002-9513
Other ID: uls-drl:31735062122951, Starzl CV No. 44
Date Deposited: 08 Apr 2010 16:59
Last Modified: 04 Aug 2020 18:56


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