Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form
D-Scholarship @ Pitt Banner and Links to Homepage

RENAL HETEROTRANSPLANTATION FROM BABOON TO MAN: EXPERIENCE WITH 6 CASES.

STARZL, TE and MARCHIORO, TL and PETERS, GN and KIRKPATRICK, CH and WILSON, WE and PORTER, KA and RIFKIND, D and OGDEN, DA and HITCHCOCK, CR and WADDELL, WR (1964) RENAL HETEROTRANSPLANTATION FROM BABOON TO MAN: EXPERIENCE WITH 6 CASES. Transplantation, 2. 752 - 776. ISSN 0041-1337

[img]
Preview
 PDF
Accepted Version
Available under License : See the attached license file.
Download (1MB) | Preview
[img] Plain Text (licence)
Available under License : See the attached license file.
Download (1kB)

Abstract

Six patients with terminal uremia due to glomerulonephritis or pyelonephritis were treated with heterografts from East African baboons. Immunosuppressive therapy was provided both before and after operation with azathioprine and prednisone and postoperatively local transplant irradiation and actinomycin C were administered intermittently. The individual rejection episodes in the post-transplant period could be reversed relatively easily but these reemred vigorously and repetitively, making it impossible to relax the stringent requirements of antirejectmion therapy. The continued need for high-dose immunosuppressive therapy precipitated lethal infections in the majority of cases. The patients lived for 19 to 98 days after heterotransplantation. Four died with the baboon kidneys still in placc after 19, 23, 35, and 49 days. In the other two cases the heterografts were removed after 60 and 49 days respectively, at a time when urine excretion was still present, and homografts from volunteer convict donors were placed on the opposite side. Both the latter recipients died of septic complications following the second operation, after 39 and 44 days. Complete cessation of heterograft urine excrelion appeared only in two cases, although rend function was failing in the remainder prior to death or before removal of the heterografts. The relation of renal function to changes in heteroagglutinin and hemagglutinin titers is described. After residence in the host for 19 to 60 days, all the heterotransplants were heavily infiltrated with plasma cells and large lymphoid cells with pyroninophilic cytoplasm. There was also disruption of peritubular capillaries, interstitial edema, widespread tubular damage, swelling of endothelial cells lining arterioles, fibrinoid necrosis of the walls of arterioles and interlobular arteries, and narrowing and obstruction of interlobular arteries by fibrin and platelet deposits on the intima. The pre-glomerular vascular lesions were accompanied by focal infarcts and extensive interstitial hemorrhages. All the pathologic changes were more severe than those seen by Reemtsma in a comparable series of chimpanzee-to-man heterotransplants, where cellular infiltration was slight and vascular lesions uncommon in the presence of major blood group incompatibility between donor and recipient.

Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
STARZL, TEtes11@pitt.eduTES11
MARCHIORO, TL
PETERS, GN
KIRKPATRICK, CH
WILSON, WE
PORTER, KA
RIFKIND, D
OGDEN, DA
HITCHCOCK, CR
WADDELL, WR
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: November 1964
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 2
Page Range: 752 - 776
DOI or Unique Handle: 10.1097/00007890-196411000-00009
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: ACTINOMYCIN, ANTIBODIES, AZATHIOPRINE, BLOOD GROUPS, CLINICAL RESEARCH, DRUG THERAPY, KIDNEY, KIDNEY FUNCTION TESTS, KIDNEY TRANSPLANTATION, MONKEYS, PATHOLOGY, PREDNISONE, TRANSPLANTATION, HETEROLOGOUS, TRANSPLANTATION, HOMOLOGOUS, UREMIA, Animals, Antibodies, Azathioprine, Biomedical Research, Blood Group Antigens, Dactinomycin, Drug Therapy, Haplorhini, Kidney, Kidney Function Tests, Kidney Transplantation, Papio, Pathology, Prednisone, Transplantation, Heterologous, Transplantation, Homologous, Uremia
ISSN: 0041-1337
Funders: NIADDK NIH HHS (R01 AM007772), NIAAA NIH HHS (A-6344), NIAAA NIH HHS (A-6283), NIDDK NIH HHS (R01 DK029961-19), NIAAA NIH HHS (HE00735-01), NIADDK NIH HHS (R01 AM007772)
Other ID: uls-drl:31735062123918, Starzl CV No. 87
Date Deposited: 08 Apr 2010 17:00
Last Modified: 03 Dec 2022 13:58
URI: http://d-scholarship.pitt.edu/id/eprint/3473

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com

Actions (login required)

View Item View Item