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Association Between BRINP3 Genetic Variation and Aggressive Periodontitis Among Arab Descents.

Alhomrany, Yazeed/M (2018) Association Between BRINP3 Genetic Variation and Aggressive Periodontitis Among Arab Descents. Master's Thesis, University of Pittsburgh. (Unpublished)

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Background: Aggressive periodontitis disease is a severe type of periodontal disease, which is characterized by enormous destruction of periodontal attachment and alveolar bone. A few loci have shown to be associated with aggressive periodontitis, which suggest a multifactorial genetic component. BRINP3 locus shows correlation with aggressive periodontitis.
Aims: To replicate the initial findings of the relationship between aggressive periodontitis and BRINP3 genetic variation (rs1342913) in group of Arab subjects.
Methods: 263 subjects were diagnosed with aggressive periodontitis. They are originally from Syria and Morocco. They are divided into: diseased (with aggressive periodontitis n= 200. Among them 49 from Syria and 151 from Morocco). and healthy (without aggressive periodontitis n= 63). Saliva was collected, then genomic DNA was extracted. One genetic marker was genotyped (BRINP3 rs1342913). PCR was run with TaqMan chemistry. Chi-square with alpha of 0.05 was utilized to test over-representation of genotypes or alleles between two groups.
Result: The frequency AA genotype is higher than GG genotype. No significant difference between allele A and allele G.
Conclusion: The frequency BRINP3 is higher in aggressive periodontitis compared with healthy cases in Arab population. Based on this result, BRINP3 gene is associated with aggressive periodontists.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Alhomrany, Yazeed/
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee MemberWilliams, Kelly/
Committee MemberSfeir, Charles/
Committee ChairVieira, Alexandre/
Date: 30 July 2018
Date Type: Publication
Defense Date: 29 May 2018
Approval Date: 30 July 2018
Submission Date: 25 July 2018
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 25
Institution: University of Pittsburgh
Schools and Programs: School of Dental Medicine > Dental Science
Degree: MDS - Master of Dental Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Aggressive periodontitis, BRINP3, Genotype, alleles, Dominant, Recessive.
Date Deposited: 30 Jul 2018 15:02
Last Modified: 02 Aug 2018 19:08


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