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Liver Allograft: Its Use in Chronic Active Hepatitis with Macronodular Cirrhosis, Hepatitis B Surface Antigen

Corman, JL and Putnam, CW and Iwatsuki, S and Redeker, AG and Porter, KA and Peters, RL and Schröter, G and Starzl, TE (1979) Liver Allograft: Its Use in Chronic Active Hepatitis with Macronodular Cirrhosis, Hepatitis B Surface Antigen. Archives of Surgery, 114 (1). 75 - 78. ISSN 0004-0010

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Abstract

A patient suffering from chronic active hepatitis with macronodular cirrhosis, positive for hepatitis B surface antigen (HB s Ag), was treated with an orthotopic liver allograft. The HB s antigenemia, as measured with several precipitation tests and by complement fixation, became negative after transplantation and remained so for about 2½ months. During the interval, very low titers of the antigen were detectable by radioimmunoassay. At about three months after transplantation, she had an attack of acute hepatitis, at which time HB s Ag became detectable by all tests. She recovered, but progressive liver disease developed during the remaining 1½ years of her life. She died of disseminated nocardiosis and candidiasis with deteriorating hepatic function. The homograft at autopsy showed no evidence of rejection, but was the site of chronic active liver disease, although of a different pathologic pattern than that affecting her native liver. The differences in histology may reflect the influence of chronic immunosuppression on the features of chronic active hepatitis. © 1979, American Medical Association. All rights reserved.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Corman, JL
Putnam, CW
Iwatsuki, S
Redeker, AG
Porter, KA
Peters, RL
Schröter, G
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1979
Date Type: Publication
Journal or Publication Title: Archives of Surgery
Volume: 114
Number: 1
Page Range: 75 - 78
DOI or Unique Handle: 10.1001/archsurg.1979.01370250077016
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0004-0010
Other ID: uls-drl:31735062109438, Starzl CV No. 341
Date Deposited: 08 Apr 2010 17:05
Last Modified: 13 Oct 2017 20:56
URI: http://d-scholarship.pitt.edu/id/eprint/3727

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