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Periaortic Adipose Tissue Relationship with Arterial Stiffness in Midlife Men

Clifton, Michelle (2020) Periaortic Adipose Tissue Relationship with Arterial Stiffness in Midlife Men. Master's Thesis, University of Pittsburgh. (Unpublished)

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Aims: Cardiovascular disease (CVD) remains as a major health concern and leading cause of death in the United states in men. Arterial stiffness is part of the aging process that alters function and may eventually lead to adverse cardiovascular event. Carotid-femoral pulse wave velocity (cfPWV) is a gold standard way of measuring stiffening of the artery and widely accepted predictor of CVD. Periaortic adipose tissue (aPVAT) is recent emerging risk marker for CVD. Because of its anatomy, aPVAT may have direct effect on vascular function. We hypothesize that aPVAT surrounding descending thoracic aorta is associated with cfPWV in biracial middle-aged men population. Then, we examined if the race moderates the relationship between aPVAT and cfPWV.
Methods: Participants were 40-49 years old and were free of CVD, type-1-diabetes, or other severe disease at the time of the recruit (n=324). cfPWV was quantified using automated waveform analyzer and aPVAT was quantified using EBT with standard attenuation values for adipose tissue (-190 to -30 HU). aPVAT volume was calculated by summing the areas and multiplying by the slice thickness.
Results: White men had higher aPVAT volume (p=0.011) but cfPWV was higher in African-American men (p=0.66). aPVAT was associated with cfPWV independent of traditional CVD risk factors (p=0.005). The association between aPVAT and cfPWV persisted after adjusting adiposity measurements, such as VAT (p=0.054)or WC (p=0.038), or BMI (p=0.052), CRP, and hypertensive, lipid, and diabetes medications. Race did not moderate the relationship between aPVAT and cfPWV (p=0.418).
Conclusion: Middle-aged men with high periaortic fat volume are more likely to have stiffer arteries independent of traditional CVD risk factors, adiposity measurements, an inflammation marker, and medications related to aPVAT and cfPWV. This work contributes to the field of public health by deepening understanding of vascular function through aPVAT in middle-aged men.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Clifton, Michellemjc183@pitt.edumjc183
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Thesis AdvisorBarinas-Mitchell, Emma
Committee MemberSekikawa, Akira
Committee MemberAlthouse, Andrew
Date: 30 July 2020
Date Type: Publication
Defense Date: 13 April 2020
Approval Date: 30 July 2020
Submission Date: 30 March 2020
Access Restriction: 2 year -- Restrict access to University of Pittsburgh for a period of 2 years.
Number of Pages: 59
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Epidemiology
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: periaortic fat arterial stiffness men
Date Deposited: 30 Jul 2020 18:06
Last Modified: 01 May 2022 05:15


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