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Cyclosporin A and steroid therapy in sixty-six cadaver kidney recipients

Starzl, TE and Klintmalm, GBG and Weil, R and Porter, KA and Iwatsuki, S and Schroter, GP and Fernandez-Bueno, C and MacHugh, N (1981) Cyclosporin A and steroid therapy in sixty-six cadaver kidney recipients. Surgery Gynecology and Obstetrics, 153 (4). 486 - 494. ISSN 0039-6087

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From nine to 18 months ago, 66 patients were given 67 randomly matched cadaveric kidneys with cyclosporin A and steroid therapy. Nine of the recipients were undergoing retransplantation. The over-all kidney survival rate to date has been 77.6 per cent, and 78.8 per cent of the recipients are dialysis-free. The patient mortality in this learning phase was 13.3 per cent. Nephrotoxicity, hepatotoxicity and other side-effects of cyclosporin A could usually be dealt with by dosage adjustments, making feasible the chronic use of this agent. One B-cell immunoblastic sarcoma was encountered which was monoclonal. It was not responsible for death. Another patient had a perforation of the intestine from a lymphoproliferative reaction in which the B cells were polyclonal. After jejunal resection a year ago, there were no further complications. This lesion was not classified as a lymphoma. Both lymphoproliferative lesions were associated with a rise in antibody to viral capsid antigen of Epstein-Barr virus. Results of this study have verified the effectiveness and relative safety of cyclosporin A with steroids for immunosuppression in human recipients of cadaveric kidneys.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Klintmalm, GBG
Weil, R
Porter, KA
Iwatsuki, S
Schroter, GP
Fernandez-Bueno, C
MacHugh, N
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 20 November 1981
Date Type: Publication
Journal or Publication Title: Surgery Gynecology and Obstetrics
Volume: 153
Number: 4
Page Range: 486 - 494
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6087
Other ID: uls-drl:31735062114354, Starzl CV No. 469
Date Deposited: 08 Apr 2010 17:07
Last Modified: 02 Feb 2019 13:56


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