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A Review of PMMA Bone Cement and Intra‐Cardiac Embolism

Shridhar, Puneeth and Chen, Yanfei and Khalil, Ramzi and Plakseychuk, Anton and Cho, Sung and Tillman, Bryan and Kumta, Prashant and Chun, YoungJae (2016) A Review of PMMA Bone Cement and Intra‐Cardiac Embolism. Materials, 9 (10). p. 821. ISSN 1996-1944

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Percutaneous vertebroplasty procedure is of major importance, given the significantly increasing aging population and the higher number of orthopedic procedures related to vertebral compression fractures. Vertebroplasty is a complex technique involving the injection of polymethylmethacrylate (PMMA) into the compressed vertebral body for mechanical stabilization of the fracture. Our understanding and ability to modify these mechanisms through alterations in cement material is rapidly evolving. However, the rate of cardiac complications secondary to PMMA injection and subsequent cement leakage has increased with time. The following review considers the main effects of PMMA bone cement on the heart, and the extent of influence of the materials on cardiac embolism. Clinically, cement leakage results in life‐threatening cardiac injury. The convolution of this outcome through an appropriate balance of complex material properties is highlighted via clinical case reports.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Chen, Yanfei
Khalil, Ramzi
Plakseychuk, Anton
Cho, Sung
Tillman, Bryan
Date: 6 October 2016
Date Type: Publication
Journal or Publication Title: Materials
Volume: 9
Number: 10
Publisher: MDPI AG
Page Range: p. 821
DOI or Unique Handle: 10.3390/ma9100821
Schools and Programs: Swanson School of Engineering > Bioengineering
Refereed: Yes
ISSN: 1996-1944
Official URL:
Article Type: Review
Date Deposited: 11 May 2020 15:55
Last Modified: 11 May 2020 15:55


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