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Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity

Scharping, Nicole and Delgoffe, Greg (2016) Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity. Vaccines, 4 (4). ISSN 2076-393X

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When a T cell infiltrates a tumor, it is subjected to a variety of immunosuppressive and regulatory signals in the microenvironment. However, it is becoming increasingly clear that due to the proliferative and energetically-deregulated nature of tumor cells, T cells also operate at a metabolic disadvantage. The nutrient dearth of the tumor microenvironment (TME) creates “metabolic checkpoints” upon infiltrating T cells, impacting their ability to survive, proliferate and function effectively. In this review, we summarize the basics of tumor cell and T cell metabolism and discuss recent advances elucidating the individual metabolic checkpoints exerted on T cells that drive their dysfunction in the TME.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Scharping, Nicolenes63@pitt.edunes63
Delgoffe, Greggmd34@pitt.edugmd34
Date: 6 December 2016
Date Type: Publication
Journal or Publication Title: Vaccines
Volume: 4
Number: 4
Publisher: MDPI AG
DOI or Unique Handle: 10.3390/vaccines4040046
Schools and Programs: School of Medicine > Immunology
Refereed: Yes
Uncontrolled Keywords: T cell, metabolism, immunotherapy, cancer, tumor microenvironment, metabolic checkpoints
ISSN: 2076-393X
Official URL:
Funders: Sidney Kimmel Foundation for Cancer Research, Skin Cancer Specialized Programs Of Research Excellence, Stand Up To Cancer and the American Association for Cancer Research
Article Type: Review
Date Deposited: 04 Feb 2021 18:08
Last Modified: 04 Feb 2021 18:08


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