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Exploration of Trends in γH2AX from Various Demographics

JADHAV, SHRUTIKA MANOHAR (2022) Exploration of Trends in γH2AX from Various Demographics. Master Essay, University of Pittsburgh.

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H2AX is an H2A histone variant that gets phosphorylated during a double-stranded break (DSB) in the DNA. It is phosphorylated at serine 139 and thus forms γ-H2AX. The formation of γ-H2AX serves as a great indicator of DNA double-stranded break. It has application potential in clinical and research settings. It can potentially be used to detect cell stresses and cancer. The data set contains demographic information about 47 subjects and measurements of C and H2AX under treatment and control conditions. The demographic data were analyzed and visualized to gain insight into its distribution. R programming language was used for statistical analysis. The analysis showed that there was no significant difference in H2AX levels among different demographics. In addition, no significant H2AX difference was seen between control and stress day visits. Additional data would be required to shed light on differences in H2AX levels among various demographics during different time points and conditions.


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Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
CreatorsEmailPitt UsernameORCID
JADHAV, SHRUTIKA MANOHARsmj59@pitt.edusmj59
ContributionContributors NameEmailPitt UsernameORCID
Thesis advisorDurst, Andreaadurst@pitt.eduadurstUNSPECIFIED
Committee MemberChernus, Jonathanjonchernus@pitt.edujonchernusUNSPECIFIED
Committee MemberFeingold, Eleanorfeingold@pitt.edufeingoldUNSPECIFIED
Date: 30 August 2022
Date Type: Completion
Submission Date: 12 August 2022
Access Restriction: 2 year -- Restrict access to University of Pittsburgh for a period of 2 years.
Number of Pages: 44
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Human Genetics
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Uncontrolled Keywords: ɣH2AX,H2AX
Date Deposited: 30 Aug 2022 16:33
Last Modified: 30 Aug 2022 16:33


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