JADHAV, SHRUTIKA MANOHAR
(2022)
Exploration of Trends in γH2AX from Various Demographics.
Master Essay, University of Pittsburgh.
Abstract
H2AX is an H2A histone variant that gets phosphorylated during a double-stranded break (DSB) in the DNA. It is phosphorylated at serine 139 and thus forms γ-H2AX. The formation of γ-H2AX serves as a great indicator of DNA double-stranded break. It has application potential in clinical and research settings. It can potentially be used to detect cell stresses and cancer. The data set contains demographic information about 47 subjects and measurements of C and H2AX under treatment and control conditions. The demographic data were analyzed and visualized to gain insight into its distribution. R programming language was used for statistical analysis. The analysis showed that there was no significant difference in H2AX levels among different demographics. In addition, no significant H2AX difference was seen between control and stress day visits. Additional data would be required to shed light on differences in H2AX levels among various demographics during different time points and conditions.
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Details
| Item Type: |
Other Thesis, Dissertation, or Long Paper
(Master Essay)
|
| Status: |
Unpublished |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| JADHAV, SHRUTIKA MANOHAR | smj59@pitt.edu | smj59 | |
|
| Contributors: |
| Contribution | Contributors Name | Email | Pitt Username | ORCID |
|---|
| Thesis advisor | Durst, Andrea | adurst@pitt.edu | adurst | UNSPECIFIED | | Committee Member | Chernus, Jonathan | jonchernus@pitt.edu | jonchernus | UNSPECIFIED | | Committee Member | Feingold, Eleanor | feingold@pitt.edu | feingold | UNSPECIFIED |
|
| Date: |
30 August 2022 |
| Date Type: |
Completion |
| Submission Date: |
12 August 2022 |
| Access Restriction: |
2 year -- Restrict access to University of Pittsburgh for a period of 2 years. |
| Number of Pages: |
44 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
School of Public Health > Human Genetics |
| Degree: |
MPH - Master of Public Health |
| Thesis Type: |
Master Essay |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
ɣH2AX,H2AX |
| Date Deposited: |
30 Aug 2022 16:33 |
| Last Modified: |
30 Aug 2022 16:33 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/43612 |
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