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Causes of death after liver transplantation in children treated with cyclosporine and steroids

Kahn, D and Esquivel, CO and Makowka, L and Madrigal-Torres, M and Yunis, E and Iwatsuki, S and Starzl, TE (1989) Causes of death after liver transplantation in children treated with cyclosporine and steroids. Clinical Transplantation, 3 (3). 150 - 155. ISSN 0902-0063

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Abstract

Two-hundred-and-twenty-seven children underwent orthotopic liver transplantation between March 1980 and March 1986. Seventy (31%) patients died during the study period. Four patients who died within 24 hours of the initial liver transplant and 5 patients who died outside of our institution were excluded from the analysis. Liver failure, related to either thrombosis of the hepatic artery, primary non-function of the graft or rejection accounted for 25 of the remaining 61 deaths. In 21 patients death was related to overwheming sepsis while 7 patients died from excessive bleeding. Eight of the deaths were due to a miscellaneous group of causes. Twenty percent of the 150 patients who received a single liver transplant died compared to a death rate of 50% in patients who underwent three transplants. Eighty-five percent of the deaths occurred within 6 months after the initial liver transplant. Liver failure was the cause in the majority of the early deaths whereas the later deaths were more likely to be due to sepsis. This detailed analysis of the causes of death after pediatric liver transplantation in a large group of patients has revealed that advances in certain areas could lead to even better results.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Kahn, D
Esquivel, CO
Makowka, L
Madrigal-Torres, M
Yunis, E
Iwatsuki, S
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1989
Date Type: Publication
Journal or Publication Title: Clinical Transplantation
Volume: 3
Number: 3
Page Range: 150 - 155
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0902-0063
Other ID: uls-drl:31735062110279, Starzl CV No. 986
Date Deposited: 08 Apr 2010 17:16
Last Modified: 02 Feb 2019 13:56
URI: http://d-scholarship.pitt.edu/id/eprint/4372

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