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Liver transplantation: Intraoperative changes in coagulation factors in 100 first transplants

Lewis, JH and Bontempo, FA and Awad, SA and Kang, YG and Kiss, JE and Ragni, MV and Spero, JA and Starzl, TE (1989) Liver transplantation: Intraoperative changes in coagulation factors in 100 first transplants. Hepatology, 9 (5). 710 - 714. ISSN 0270-9139

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Abstract

Six intraoperative blood samples were obtained at intervals from each of 100 individuals undergoing their first liver transplants. The patients fell into the following diagnostic categories: postnecrotic cirrhosis 28, primary biliary cirrhosis 20, sclerosing cholangitis 19, miscellaneous diseases 14, carcinoma/neoplasia 12 and fulminant hepatitis 7. Coagulation factor values in the initial (baseline) blood samples varied by patient diagnosis. In general, all factor levels were reduced except factor VIII:C, which was increased to almost twice normal. The slight intraoperative changes in factors II, VII, IX, X, XI and XII suggested that a steady‐state relationship existed between depletion (consumption/bleeding) and repletion (transfusion, transit from extra‐ to intravascular space), even in the anhepatic state. In contrast, there were rapid and very significant falls in factor VIII and fibrinogen and a less pronounced decrease in factor V, all reaching their nadirs in early to mid‐Stage III. The cause of these coagulation changes appears to be activation of the fibrinolytic system. Copyright © 1989 American Association for the Study of Liver Diseases


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Lewis, JH
Bontempo, FA
Awad, SA
Kang, YG
Kiss, JEjek10@pitt.eduJEK10
Ragni, MV
Spero, JA
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1989
Date Type: Publication
Journal or Publication Title: Hepatology
Volume: 9
Number: 5
Page Range: 710 - 714
DOI or Unique Handle: 10.1002/hep.1840090509
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0270-9139
Other ID: uls-drl:31735062110519, Starzl CV No. 1010
Date Deposited: 08 Apr 2010 17:17
Last Modified: 03 Feb 2019 04:55
URI: http://d-scholarship.pitt.edu/id/eprint/4396

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