Murase, N and Lieberman, I and Nalesnik, MA and Mintz, DH and Todo, S and Drash, AL and Starzl, TE
(1990)
Effect of FK 506 on spontaneous diabetes in BB rats.
Diabetes, 39 (12).
1584 - 1586.
ISSN 0012-1797
Abstract
From days 30-120 after birth, 59 BB rats were treated with water (n = 20) or FK 506 in intragastric doses of 1 mg·kg-1·day-1 (n = 19) or 2 mg·kg-1·day-1 (n = 20). Diabetes developed in 75, 15, and 0% of the 3 groups, respectively. Animals protected from diabetes by FK 506 had normal intraperitoneal glucose tolerance tests, virtual absence histopathologically of autoimmune insulitis, and normal pancreatic insulin content. Forty-five to 75 days after stopping FK 506, ∼75% of the rats that were diabetes free at 120 days remained so.
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