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The effect of graft function on FK506 plasma levels, dosages, and renal function, with particular reference to the liver

Abu-Elmagd, K and Fung, JJ and Alessiani, M and Jain, A and Venkataramanan, R and Warty, VS and Takaya, S and Todo, S and Shannon, WD and Starzl, TE (1991) The effect of graft function on FK506 plasma levels, dosages, and renal function, with particular reference to the liver. Transplantation, 52 (1). 71 - 77. ISSN 0041-1337

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Abstract

Plasma FK506 was studied in 49 liver, 13 heart, 3 double-lung or heart-lung, and 21 kidney recipients. The levels were correlated with the drug doses used, kidney function, and liver function. In all varieties of recipients, there was an early rise in the FK506 plasma levels that occurred at the time of intravenous administration of the drug. At the same time or shortly after, there were increases in serum creatinine that were transitory except in liver recipients with continuing suboptimal graft function. The quality of hepatic function dominated all aspects of FK506 management in the liver recipients. Those who received well-functioning grafts could be given about the same drug doses as recipients of kidneys and the thoracic organs. Liver recipients with defective grafts had astronomical rises in plasma FK506, a high incidence of renal failure, and probably increased neurotoxicity. In kidney transplant recipients, the FK506 plasma levels and doses were essentially the same in patients with prompt versus delayed renal function. These studies have highlighted the necessity, first, of close pharmacologic monitoring of patients who are given FK506 in the presence of abnormal liver function, and second, of using smaller intravenous induction doses than in past practice. © 1991 by Williams & Wilkins.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Abu-Elmagd, K
Fung, JJ
Alessiani, M
Jain, A
Venkataramanan, Rrv@pitt.eduRV
Warty, VS
Takaya, S
Todo, S
Shannon, WD
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1991
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 52
Number: 1
Page Range: 71 - 77
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062117555, Starzl CV No. 1203
Date Deposited: 08 Apr 2010 17:20
Last Modified: 13 Oct 2017 22:55
URI: http://d-scholarship.pitt.edu/id/eprint/4589

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