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Screening donors for xenotransplantation: The potential for xenozoonoses

Michaels, MG and McMichael, JP and Kahleen, B and Kalter, S and Peters, RL and Starzl, TE and Simmons, RL (1994) Screening donors for xenotransplantation: The potential for xenozoonoses. Transplantation, 57 (10). 1462 - 1465. ISSN 0041-1337

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Abstract

Xenotransplantation is a potential solution to the current donor shortage for solid organ transplantation. The transmission of infectious agents from donor organs or bone marrow to the recipient is a well-recognized phenomenon following allotransplantation. Thus the prospect of xenotransplantation raises the issue of xenozoonoses-i.e., the transmission of animal infections to the human host. Anticipating an increasing number of baboon to human transplants, 31 adult male baboons (Papio cynocephalus) from a single colony in the United States were screened for the presence of antibody to microbial agents (principally viral) that may pose a significant risk of infection. Antibody to simian cytomegalovirus, simian agent 8 and Epstein-Barr virus, was found in 97% of animals tested. Antibody to simian retroviruses and Toxoplasma gondii was found in 30% and 32% respectively. Discordant results were found when paired samples were examined by two primate laboratories. This was particularly noted when methodologies were based on cross-reaction with human viral antigens. These results highlight the need to develop specific antibody tests against the species used for xenotransplantation. © 1994 Williams & Wilkins.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Michaels, MG
McMichael, JP
Kahleen, B
Kalter, S
Peters, RL
Starzl, TEtes11@pitt.eduTES11
Simmons, RL
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1994
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 57
Number: 10
Page Range: 1462 - 1465
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062125822, Starzl CV No. 1629
Date Deposited: 08 Apr 2010 17:27
Last Modified: 13 Oct 2017 20:56
URI: http://d-scholarship.pitt.edu/id/eprint/5015

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