Michaels, MG and McMichael, JP and Kahleen, B and Kalter, S and Peters, RL and Starzl, TE and Simmons, RL
(1994)
Screening donors for xenotransplantation: The potential for xenozoonoses.
Transplantation, 57 (10).
1462 - 1465.
ISSN 0041-1337
Abstract
Xenotransplantation is a potential solution to the current donor shortage for solid organ transplantation. The transmission of infectious agents from donor organs or bone marrow to the recipient is a well-recognized phenomenon following allotransplantation. Thus the prospect of xenotransplantation raises the issue of xenozoonoses-i.e., the transmission of animal infections to the human host. Anticipating an increasing number of baboon to human transplants, 31 adult male baboons (Papio cynocephalus) from a single colony in the United States were screened for the presence of antibody to microbial agents (principally viral) that may pose a significant risk of infection. Antibody to simian cytomegalovirus, simian agent 8 and Epstein-Barr virus, was found in 97% of animals tested. Antibody to simian retroviruses and Toxoplasma gondii was found in 30% and 32% respectively. Discordant results were found when paired samples were examined by two primate laboratories. This was particularly noted when methodologies were based on cross-reaction with human viral antigens. These results highlight the need to develop specific antibody tests against the species used for xenotransplantation. © 1994 Williams & Wilkins.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Michaels, MG | | | | | McMichael, JP | | | | | Kahleen, B | | | | | Kalter, S | | | | | Peters, RL | | | | | Starzl, TE | tes11@pitt.edu | TES11 | | | Simmons, RL | | | |
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| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
1 January 1994 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Transplantation |
| Volume: |
57 |
| Number: |
10 |
| Page Range: |
1462 - 1465 |
| DOI or Unique Handle: |
10.1097/00007890-199405000-00011 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
0041-1337 |
| Other ID: |
uls-drl:31735062125822, Starzl CV No. 1629 |
| Date Deposited: |
08 Apr 2010 17:27 |
| Last Modified: |
03 Aug 2020 14:57 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/5015 |
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