Shapiro, R and Jordan, M and Scantlebury, VP and Vivas, C and Gritsch, HA and Rao, AS and Trucco, M and Zeevi, A and Demetris, AJ and Randhawa, P
(1994)
Renal transplantation at the University of Pittsburgh: the impact of FK506.
Clinical transplants.
229 - 236.
ISSN 0890-9016
Abstract
1. In an unselected adult renal transplant population, FK506 as the primary immunosuppressive agent yielded one- and 2-year actuarial patient survival rates of 95% and 93% and one- and 2-year actuarial graft survival rates of 89% and 83%, respectively. Forty-nine percent of successfully transplanted patients were weaned off steroids. 2. In pediatric renal transplant patients, FK506 has been associated with 100% one- and 3-year actuarial patient survival rates and 98% and 85% one- and 3-year actuarial graft survival rates, respectively. Sixty-two percent of successfully transplanted patients were taken off prednisone, with dramatic improvements in height. 3. FK506 has been used successfully in rescuing 70-74% of adult or pediatric renal transplant patients with an acute rejection that failed conventional therapy. 4. Kidney/bone marrow transplantation under FK506 therapy has been successfully performed without graft-versus-host disease and with routine augmentation of chimerism. 5. The side effects of FK506 included nephrotoxicity, neurotoxicity, and diabetogenicity; they were comparable to those seen with CsA. 6. FK506 is an important new addition to the immunosuppressive armamentarium in renal transplant patients.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID ![](/images/orcid_id_24x24.png) |
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Shapiro, R | | | | Jordan, M | | | | Scantlebury, VP | | | | Vivas, C | | | | Gritsch, HA | | | | Rao, AS | | | | Trucco, M | mnt@pitt.edu | MNT | | Zeevi, A | | | | Demetris, AJ | | | | Randhawa, P | | | |
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Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
Date: |
1 January 1994 |
Date Type: |
Publication |
Journal or Publication Title: |
Clinical transplants |
Page Range: |
229 - 236 |
Institution: |
University of Pittsburgh |
Refereed: |
Yes |
ISSN: |
0890-9016 |
Other ID: |
uls-drl:31735062126531, Starzl CV No. 1776 |
PubMed ID: |
7547544 |
Date Deposited: |
08 Apr 2010 17:30 |
Last Modified: |
18 Feb 2019 14:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/5162 |
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