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Lazaroid U-74389G for 48-hour canine liver preservation

Todo, S and Hamada, N and Zhu, Y and Zhang, S and Subbotin, V and Nemoto, A and Takeyoshi, I and Starzl, TE (1996) Lazaroid U-74389G for 48-hour canine liver preservation. Transplantation, 61 (2). 189 - 194. ISSN 0041-1337

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Lazaroids have been reported to attenuate preservation and reperfusion injury. In this study, we examined whether lazaroids can improve the outcome after 48-hr canine liver preservation and transplantation. Adult female beagle dogs were randomized into 4 dosage groups (5 animals each). Lazaroid U-74389G was intravenously administered at a dose of 0 mg/kg, 6 mg/kg, 10 mg/kg, or 15 mg/kg to donors 30 min before harvesting and also to recipients 30 min before revascularization. Control animals (0 mg/kg) were given the lazaroid vehicle. The liver grafts were orthotopically transplanted after 48 hr of hypothermic preservation in UW solution. Lazaroid treatment significantly improved outcome after transplantation. Five-day animal survival increased from 0% in the control to 60% in the 6 mg/kg group, 100% in the 10 mg/kg group, and 80% in the 15 mg/kg group. Lazaroid protected the hepatocytes from damage during preservation, and enhanced energy charge and hepatic blood flow after reperfusion. Histological alterations were significantly less severe in the lazaroid-treated groups. The area of necrotic hepatocytes decreased from 43.7±17.7 in the control to 13.5±3.0 in the lazaroid 10 mg/kg group. These results indicate that lazaroid U-74389G has potential for improvement of clinical liver preservation.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Todo, S
Hamada, N
Zhu, Y
Zhang, S
Subbotin, V
Nemoto, A
Takeyoshi, I
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 27 January 1996
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 61
Number: 2
Page Range: 189 - 194
DOI or Unique Handle: 10.1097/00007890-199601270-00004
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Other ID: uls-drl:31735062121714, Starzl CV No. 1819
Date Deposited: 08 Apr 2010 17:31
Last Modified: 02 Feb 2019 13:57


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