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Endotoxemia is associated with penal dysfunction in liver transplantation recipients during the first postoperative week

Yokoyama, I and Gavaler, JS and Todo, S and Miyata, T and Van Thiel, DH and Starzl, TE (1995) Endotoxemia is associated with penal dysfunction in liver transplantation recipients during the first postoperative week. Hepato-Gastroenterology, 42 (3). 205 - 208. ISSN 0172-6390

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Abstract

The effect of endotoxemia on renal function was studied in 76 orthotopic liver transplant patients. In the preoperative period, a high preoperative serum creatinine revel ( > 2.0 mg/dl) was significantly associated with postoperative endotoxemia. The serum total bilirubin lever was significantly greater in the patients with high serum creatinine levels than in those with lower serum creatinine revels ( < 2.0 mg/dl). On the 7th postoperative day (POD), the serum creatinine level was significantly associated with an increased plasma endotoxin level. The serum total bilirubin and AST levels did not differ significantly between the patients with high and those with low serum creatinine revels. Based upon these data postoperative endotoxemia is suspected as being the principal cause of early postoperative renal dysfunction. A synergistic effect on renal function between cyclosporine and endotoxin may be important in the pathogenesis of the renal dysfunction seen after successful liver transplantation.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Yokoyama, I
Gavaler, JS
Todo, S
Miyata, T
Van Thiel, DH
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1995
Date Type: Publication
Journal or Publication Title: Hepato-Gastroenterology
Volume: 42
Number: 3
Page Range: 205 - 208
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0172-6390
Other ID: uls-drl:31735062133073, Starzl CV No. 1843
Date Deposited: 08 Apr 2010 17:31
Last Modified: 25 Nov 2017 12:55
URI: http://d-scholarship.pitt.edu/id/eprint/5229

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