Yokoyama, I and Gavaler, JS and Todo, S and Miyata, T and Van Thiel, DH and Starzl, TE
(1995)
Endotoxemia is associated with penal dysfunction in liver transplantation recipients during the first postoperative week.
Hepato-Gastroenterology, 42 (3).
205 - 208.
ISSN 0172-6390
Abstract
The effect of endotoxemia on renal function was studied in 76 orthotopic liver transplant patients. In the preoperative period, a high preoperative serum creatinine revel (> 2.0 mg/dl) was significantly associated with postoperative endotoxemia. The serum total bilirubin lever was significantly greater in the patients with high serum creatinine levels than in those with lower serum creatinine revels (< 2.0 mg/dl). On the 7th postoperative day (POD), the serum creatinine level was significantly associated with an increased plasma endotoxin level. The serum total bilirubin and AST levels did not differ significantly between the patients with high and those with low serum creatinine revels. Based upon these data postoperative endotoxemia is suspected as being the principal cause of early postoperative renal dysfunction. A synergistic effect on renal function between cyclosporine and endotoxin may be important in the pathogenesis of the renal dysfunction seen after successful liver transplantation.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID ![](/images/orcid_id_24x24.png) |
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Yokoyama, I | | | | Gavaler, JS | | | | Todo, S | | | | Miyata, T | | | | Van Thiel, DH | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
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Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
Date: |
1 January 1995 |
Date Type: |
Publication |
Journal or Publication Title: |
Hepato-Gastroenterology |
Volume: |
42 |
Number: |
3 |
Page Range: |
205 - 208 |
Institution: |
University of Pittsburgh |
Refereed: |
Yes |
ISSN: |
0172-6390 |
Other ID: |
uls-drl:31735062133073, Starzl CV No. 1843 |
Date Deposited: |
08 Apr 2010 17:31 |
Last Modified: |
02 Feb 2019 13:57 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/5229 |
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