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Changes in Fat Oxidation with Endurance Activity in Adults with and without Type 2 Diabetes

Mathews, Anne (2008) Changes in Fat Oxidation with Endurance Activity in Adults with and without Type 2 Diabetes. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Impaired metabolism of fatty acids is associated with obesity and type 2 diabetes (T2D). Basedon evidence in lean adults, the expected response of skeletal muscle to aerobic training is anincrease in the oxidation of fatty acids. However, considerably less is known about the responseof fat oxidation to aerobic training in those with obesity and/or T2D. PURPOSE: 1) Todetermine if sedentary overweight adults with and without type 2 diabetes exhibit significantimprovements in fatty acid metabolism at rest and during physical activity due to endurancetraining. 2) To compare changes in the oxidation of intramuscular triacylglycerols (IMTG)during sub-maximal exercise between those with and without T2D. METHODS: 13 (10without T2D, 3 with T2D) overweight (BMI: 28-40 kg/m2) men and women aged 28-55completed an 8-week aerobic exercise intervention. Pre and post intervention, all subjectsunderwent a DEXA, maximal graded exercise test, and indirect calorimetry with non-radioactivelabeled isotopes palmitate and acetate to determine energy expenditure, fat oxidation, and sourceof fatty acids for oxidation at rest and during exercise. RESULTS: VO2max improved by anaverage of 14% (40.8+1.6 to 46.5+1.7ml/kg LBM/min) in the OW group (p<0.01) and 13.4%(34.8+4.5 to 38.0+1.7 ml/kg/LBM/min) in the T2D group (p=0.10). A non-significant increasein whole body fat oxidation during exercise was measured in both the OW (6.2%) and T2D(5.1%) group. There were no changes in whole body fat oxidation at rest in either group. Beforeand after intervention, IMTG oxidation during exercise was 4.13 + 1.7 and 5.5 + 2.3 uMol/kgChanges in Fat Oxidation with Endurance Activity inAdults with and without Type 2 DiabetesAnne Mathews, RD, PhDUniversity of Pittsburgh, 2008vLBM/min in OW and 3.42 + 1.9 and 2.41 + 2.8 uMol/kg LBM/min in T2D. These changes werenot significant due to the intervention (p=0.62). CONCLUSIONS: Eight weeks of moderateintensity aerobic exercise results in increased cardiorespiratory fitness but not a significantincrease in whole body fatty acid oxidation during rest and exercise in overweight adults with orwithout type 2 diabetes. Moreover, oxidation of fatty acids from IMTG was not enhanced by the8-week intervention.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairGoodpaster, Bretbgood@pitt.eduBGOOD
Committee MemberOtto, Amyayotto@pitt.eduAYOTTO
Committee MemberToledo,
Committee MemberJakicic, Johnjjakicic@pitt.eduJJAKICIC
Date: 29 September 2008
Date Type: Completion
Defense Date: 4 June 2008
Approval Date: 29 September 2008
Submission Date: 22 July 2008
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: School of Education > Health, Physical, Recreational Education
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: fatty acid oxidation; IMCL; obesity; substrate utilization; beta oxidation; endurance exercise
Other ID:, etd-07222008-110748
Date Deposited: 10 Nov 2011 19:52
Last Modified: 15 Nov 2016 13:46


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