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Synthesis of Potential SH2 Domain Ligands Containing Phosphate Group Mimics

Ware, Nathaniel F. (2011) Synthesis of Potential SH2 Domain Ligands Containing Phosphate Group Mimics. Master's Thesis, University of Pittsburgh. (Unpublished)

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This thesis describes the synthesis of two peptidomimetics containing heterocyclicphosphate group mimics. These compounds are based on a potent STAT3 inhibitor andtherefore have the potential of being SH2 domain ligands. Due to problems with the purificationof the final products, the mimetic containing the isothiazolidinone (IZD) moiety was obtained in< 87% purity and the 5,6-dihydro-2H-1,2,6-thiadiazine 1,1-dioxide (TDA) analog was isolated in< 57% purity based on NMR analysis.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Ware, Nathaniel
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairWipf, Peterpwipf@pitt.eduPWIPF
Committee MemberCurran, Dennis P.curran@pitt.eduCURRAN
Committee MemberKoide, Kazunorikoide@pitt.eduKOIDE
Date: 14 September 2011
Date Type: Completion
Defense Date: 19 August 2011
Approval Date: 14 September 2011
Submission Date: 15 August 2011
Access Restriction: 5 year -- Restrict access to University of Pittsburgh for a period of 5 years.
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: medicinal chemistry; peptide coupling; peptidomimetic; STAT3 target
Other ID:, etd-08152011-110256
Date Deposited: 10 Nov 2011 19:59
Last Modified: 15 Nov 2016 13:49


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