Characterization of a Mycobacterium Smegmatis Mutant that is Simultaneously Resistant to D-Cycloserine and Vancomycin.

Peteroy, M and Severin, A and Zhao, F and Rosner, D and Lopatin, U and Scherman, H and Belanger, A and Harvey, B and Hatfull, Graham F and Brennan, PJ and Connell, ND (2000) Characterization of a Mycobacterium Smegmatis Mutant that is Simultaneously Resistant to D-Cycloserine and Vancomycin. Antimicrobial agents and chemotherapy, 44 (6). 1701 - 1704. ISSN 0066-4804

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Abstract

A mutant of Mycobacterium smegmatis has been isolated that is simultaneously resistant to both D-cycloserine (D-CS) and vancomycin. Genetic complementation with a PBP4 homolog restores sensitivity to both drugs. Resistance to D-CS and vancomycin in this mutant is most likely due to a novel mechanism involving peptidoglycan assembly at the cell surface.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Peteroy, M Severin, A Zhao, F Rosner, D Lopatin, U Scherman, H Belanger, A Harvey, B Hatfull, Graham F gfh@pitt.edu GFH Brennan, PJ Connell, ND
Date:	June 2000
Date Type:	Publication
Journal or Publication Title:	Antimicrobial agents and chemotherapy
Volume:	44
Number:	6
Publisher:	American Society for Microbiology
Page Range:	1701 - 1704
DOI or Unique Handle:	10.1128/aac.44.6.17-1-1704.2000
Schools and Programs:	Dietrich School of Arts and Sciences > Biological Sciences
Refereed:	Yes
ISSN:	0066-4804
Article Type:	Research Article
MeSH Headings:	Amino Acid Sequence; Cycloserine--pharmacology; Drug Resistance, Microbial; Molecular Sequence Data; Mutation; Mycobacterium smegmatis--drug effects; Mycobacterium smegmatis--genetics; Sequence Alignment; Vancomycin--pharmacology; Vancomycin Resistance
Other ID:	NLM PMC89937
PubMed Central ID:	PMC89937
PubMed ID:	10817733
Date Deposited:	05 Dec 2012 16:39
Last Modified:	27 Sep 2022 14:55
URI:	http://d-scholarship.pitt.edu/id/eprint/16637

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