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Regulation of Focal Adhesion Dynamics by a Kinesin Motor Kid/KIF22/Kinesin-10

XU, LINGQING (2016) Regulation of Focal Adhesion Dynamics by a Kinesin Motor Kid/KIF22/Kinesin-10. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Abstract

Cell adhesion is one of the fundamental mechanisms cells use to interact with their surrounding environment. It is mediated by multiprotein structures termed focal adhesions (FAs). The formation of FAs and the regulation of their assembly and disassembly dynamics are crucial to cell structure and viability. In my dissertation study, I explored the role of a kinesin motor Kid/kinesin-10/KIF22 in adhesion dynamics. I found that Kid localizes to the sites of FAs and functions as an adhesion disassembly factor by modulating the phosphorylation of two important components of FAs, focal adhesion kinase (FAK) and paxillin. Loss of Kid caused changes in the density, distribution, and size of FAs leading to defects in cell adhesion and migration. This study discovered a novel function of Kid during interphase and expanded our knowledge on how motor proteins play significant roles in adhesion dynamics.

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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
XU, LINGQINGlix16@pitt.eduLIX16
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairSaunders, Williamwsaund@pittedu
Committee MemberBerman, Andreaajb190@pitt.edu
Committee MemberHendrix, Rogerrhx@pitt.edu
Committee MemberKiselyov, Kirillkiselyov@pitt.edu
Committee MemberWatkins, Simonsimon.watkins@pitt.edu
Date: 3 October 2016
Date Type: Publication
Defense Date: 27 June 2016
Approval Date: 3 October 2016
Submission Date: 11 August 2016
Access Restriction: 2 year -- Restrict access to University of Pittsburgh for a period of 2 years.
Number of Pages: 130
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Biological Sciences
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: KIF22, Focal Adhesions, Adhesion Dynamics, Focal Adhesion Kinase
Date Deposited: 03 Oct 2016 20:55
Last Modified: 03 Oct 2018 05:15
URI: http://d-scholarship.pitt.edu/id/eprint/29238

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