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Use of Micropatterned Thin Film Nitinol in Carotid Stents to Augment Embolic Protection

Shayan, Mahdis and Jankowitz, Brian and Shridhar, Puneeth and Chun, Youngjae (2016) Use of Micropatterned Thin Film Nitinol in Carotid Stents to Augment Embolic Protection. Journal of Functional Biomaterials, 7 (4). p. 34. ISSN 2079-4983

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Abstract

Stenting is an alternative to endarterectomy for the treatment of carotid artery stenosis. However, stenting is associated with a higher risk of procedural stroke secondary to distal thromboembolism. Hybrid stents with a micromesh layer have been proposed to address this complication. We developed a micropatterned thin film nitinol (M-TFN) covered stent designed to prevent thromboembolism during carotid intervention. This innovation may obviate the need or work synergistically with embolic protection devices. The proposed double layered stent is low-profile, thromboresistant, and covered with a M-TFN that can be fabricated with fenestrations of varying geometries and sizes. The M-TFN was created in multiple geometries, dimensions, and porosities by sputter deposition. The efficiency of various M-TFN to capture embolic particles was evaluated in different atherosclerotic carotid stenotic conditions through in vitro tests. The covered stent prevented emboli dislodgement in the range of 70%–96% during 30 min duration tests. In vitro vascular cell growth study results showed that endothelial cell elongation, alignment and growth behaviour silhouettes significantly enhance, specifically on the diamond-shape M-TFN, with the dimensions of 145 µm × 20 µm and a porosity of 32%. Future studies will require in vivo testing. Our results demonstrate that M-TFN has a promising potential for carotid artery stenting.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Shayan, Mahdis
Jankowitz, Brian
Shridhar, Puneethpus8@pitt.edu
Chun, Youngjaeyjchun@pitt.edu
Date: 13 December 2016
Date Type: Publication
Journal or Publication Title: Journal of Functional Biomaterials
Volume: 7
Number: 4
Publisher: MDPI AG
Page Range: p. 34
DOI or Unique Handle: 10.3390/jfb7040034
Schools and Programs: Swanson School of Engineering > Bioengineering
Refereed: Yes
ISSN: 2079-4983
Official URL: http://dx.doi.org/10.3390/jfb7040034
Article Type: Research Article
Date Deposited: 13 May 2020 15:24
Last Modified: 13 May 2020 15:24
URI: http://d-scholarship.pitt.edu/id/eprint/38984

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