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Drug interaction of oral anticoagulants and dexamethasone, a nested case control study in the National COVID Cohort Collaborative (N3C)

Kravchenko, Olga V. and Gomez-Lumbreras, Ainhoa and Kocis, Paul T. and Malone, Daniel and Leonard, Charles E. and Boyce, Richard D. (2021) Drug interaction of oral anticoagulants and dexamethasone, a nested case control study in the National COVID Cohort Collaborative (N3C). In: National Library of Medicine Informatics Training Conference 2021, June 21-23, Seattle. (Unpublished)

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Abstract

We report on our use of the National COVID Cohort Collaborative (N3C) Data Enclave platform to examine the rate of thromboembolic events in COVID-19 patients exposed concomitantly to dexamethasone and a direct oral anticoagulant (DOAC), compared to those taking a DOAC alone. In this poster we will discuss the lessons we learned conducting this study which is the first drug-drug interaction (DDI) study to take place within the N3C Data Enclave.


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Details

Item Type: Conference or Workshop Item (Poster)
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Kravchenko, Olga V.kravchen@pitt.edu0000-0002-8069-8773
Gomez-Lumbreras, AinhoaAinhoa.Gomez-Lumbreras@pharm.utah.edu
Kocis, Paul T.pkocis@pennstatehealth.psu.edu
Malone, Danieldan.malone@utah.edu
Leonard, Charles E.celeonar@pennmedicine.upenn.edu
Boyce, Richard D.rdb20@pitt.edu
Date: 23 June 2021
Event Title: National Library of Medicine Informatics Training Conference 2021
Event Dates: June 21-23
Event Type: Conference
Schools and Programs: School of Medicine > Biomedical Informatics
Refereed: No
Uncontrolled Keywords: COVID-19, drug-drug interaction, thromboembolic, DOAC, dexamethasone
Funders: NLM T15 grant 5T15LM007059-34
Date Deposited: 28 Jun 2021 14:23
Last Modified: 28 Jun 2021 14:23
URI: http://d-scholarship.pitt.edu/id/eprint/41334

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