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Balanced synaptic input shapes the correlation between neural spike trains

Litwin-Kumar, A and Oswald, AMM and Urban, NN and Doiron, B (2011) Balanced synaptic input shapes the correlation between neural spike trains. PLoS Computational Biology, 7 (12). ISSN 1553-734X

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Abstract

Stimulus properties, attention, and behavioral context influence correlations between the spike times produced by a pair of neurons. However, the biophysical mechanisms that modulate these correlations are poorly understood. With a combined theoretical and experimental approach, we show that the rate of balanced excitatory and inhibitory synaptic input modulates the magnitude and timescale of pairwise spike train correlation. High rate synaptic inputs promote spike time synchrony rather than long timescale spike rate correlations, while low rate synaptic inputs produce opposite results. This correlation shaping is due to a combination of enhanced high frequency input transfer and reduced firing rate gain in the high input rate state compared to the low state. Our study extends neural modulation from single neuron responses to population activity, a necessary step in understanding how the dynamics and processing of neural activity change across distinct brain states. © 2011 Litwin-Kumar et al.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Litwin-Kumar, A
Oswald, AMM
Urban, NNnurban@pitt.eduNURBAN0000-0002-0365-9068
Doiron, Bbdoiron@pitt.eduBDOIRON
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorSporns, OlafUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 1 December 2011
Date Type: Publication
Journal or Publication Title: PLoS Computational Biology
Volume: 7
Number: 12
DOI or Unique Handle: 10.1371/journal.pcbi.1002305
Schools and Programs: Dietrich School of Arts and Sciences > Mathematics
Refereed: Yes
ISSN: 1553-734X
MeSH Headings: Action Potentials--physiology; Animals; Brain--physiology; Mice; Mice, Inbred Strains; Models, Neurological; Neurons--physiology; Synaptic Transmission--physiology
Other ID: NLM PMC3245294
PubMed Central ID: PMC3245294
PubMed ID: 22215995
Date Deposited: 07 Sep 2012 19:34
Last Modified: 04 Feb 2019 15:56
URI: http://d-scholarship.pitt.edu/id/eprint/14007

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