Lu, TY and Yang, L
(2011)
Uses of cardiomyocytes generated from induced pluripotent stem cells.
Stem Cell Research and Therapy, 2 (6).
Abstract
Embryonic stem (ES) cells are naturally derived from early stage embryos and induced pluripotent stem (iPS) cells are reprogrammed from somatic cells with overexpression of four reprogramming factors, Oct4, Sox2, Klf4 and c-Myc. Both ES cells and iPS cells are pluripotent stem cells with capabilities of indefi nite self-renewal and can be diff erentiated into almost all cell types of the body, which make them valuable for studying early developmental biology, for modeling and as therapy for human diseases. Specifi cally, human iPS cells could be utilized to generate patient-specifi c lineages for a variety of translational research. In this review, we describe the cardiac diff erentiation from ES cells, iPS cells, and the current progress of using iPS cell-derived cardiomyocytes for heart disease modeling and for the development of therapeutic strategies. In addition, we summarize the recent direct reprogramming of cardiomyocytes from fi broblast cells, which provides another method for potential heart disease therapy. © 2011 BioMed Central Ltd.
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