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Improvements in the preparation of heterologous antilymphocyte globulin with special reference to absorption and diethylaminoethyl cellulose batch production

Kashiwagi, N and Groth, CG and Amend, JR and Gecelter, L and Blanchard, H and Starzl, TE (1969) Improvements in the preparation of heterologous antilymphocyte globulin with special reference to absorption and diethylaminoethyl cellulose batch production. Surgery, 65 (3). 477 - 484. ISSN 0039-6060

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Abstract

Antilymphocyte gamma-G globulin (ALGG) was produced from the serum of immunized horses. Modifications of the preliminary absorption techniques permitted the removal of undesirable, extraneous antibodies. With the use of a batch technique, pure gamma-G globulin could then be removed in bulk quantities. The resulting product was first confirmed to have immunosuppressive qualities in dogs and then given a clinical trial. In patients, its administration occasionally caused low-grade fever and thrombocytopenia. Pain at the injection site was not eliminated. Precipitin antibody responses have apparently been prevented in the patients but not a host response to Forssman antigens. © 1969.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Kashiwagi, N
Groth, CG
Amend, JR
Gecelter, L
Blanchard, H
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 March 1969
Date Type: Publication
Journal or Publication Title: Surgery
Volume: 65
Number: 3
Page Range: 477 - 484
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0039-6060
Other ID: uls-drl:31735062124346, Starzl CV No. 169
Date Deposited: 08 Apr 2010 17:02
Last Modified: 02 Feb 2019 13:57
URI: http://d-scholarship.pitt.edu/id/eprint/3555

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