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The role of a PGC1-alpha variation in patient outcomes after severe traumatic brain injury

Loudenslager, Emilie (2020) The role of a PGC1-alpha variation in patient outcomes after severe traumatic brain injury. Undergraduate Thesis, University of Pittsburgh. (Unpublished)

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Abstract

A traumatic brain injury (TBI) is damage to the brain resulting from a blow or jolt to the head. Despite enduring similar extent of injuries and receiving similar treatment measures, some individuals recover much faster than others with little to no long lasting deficits. With mechanism of injury and environment of treatment being similar, these differences in recovery could indicate a potential genetic component. This study aimed to investigate the relationship between a single nucleotide polymorphism (SNP) of PGC1-alpha and outcomes following severe TBI. PGC1-alpha is heavily involved in several metabolic processes such as mitochondrial biogenesis, fatty acid oxidation, thermogenesis and several more. Despite this genes involvement in these processes, there has been no formal investigation into the role that PGC1-alpha plays following a TBI, warranting a need for a study of this nature.
Participants (n=429) were recruited from the University of Pittsburgh Medical Center (UPMC) Presbyterian Hospital following a severe TBI with a Glasgow Coma Score ≤8 and followed for 24 months post-injury to evaluate long term outcomes. Outcomes were evaluated using the Glasgow Outcome Scale (GOS), Neurobehavioral Rating Scale (NRS), and Disability Rating Scale (DRS). Allelic Discrimination of the SNP rs8192678 was performed using a taqman assay. Individuals with the CC genotype were found to have better outcomes on the NRS at the 3 month post-injury timepoint when compared to individuals with the CT/TT genotypes. These findings show that PGC1-alpha may play a role in TBI recovery and warrants further investigation of the role PGC1-alpha plays in recovery after TBI.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Loudenslager, Emilieecl47@pitt.eduecl47
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairConley, Yvetteyconley@pitt.eduyconley
Committee MemberRen, Dianxudir8@pitt.edudir8
Committee MemberAlexander, Sheilasalexand@pitt.edusalexand
Committee MemberReuter-Rice, Karinkarin.reuter-rice@duke.edu
Date: 4 May 2020
Date Type: Publication
Defense Date: 9 April 2020
Approval Date: 4 May 2020
Submission Date: 14 April 2020
Access Restriction: 1 year -- Restrict access to University of Pittsburgh for a period of 1 year.
Number of Pages: 29
Institution: University of Pittsburgh
Schools and Programs: University Honors College
School of Nursing > Nursing
Degree: BSN - Bachelor of Science in Nursing
Thesis Type: Undergraduate Thesis
Refereed: Yes
Uncontrolled Keywords: Traumatic Brain Injury, Single Nucleotide Polymorphism, patient outcomes, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha (PGC1-alpha), Gly482Ser
Date Deposited: 04 May 2020 21:27
Last Modified: 04 May 2021 05:15
URI: http://d-scholarship.pitt.edu/id/eprint/38712

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