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Impaired clearance of ceftizoxime and cefotaxime after orthotopic liver transplantation.

Burckart, GJ and Ptachcinski, RJ and Jones, DH and Howrie, DL and Venkataramanan, R and Starzl, TE (1987) Impaired clearance of ceftizoxime and cefotaxime after orthotopic liver transplantation. Antimicrob Agents Chemother, 31 (2). 323 - 324. ISSN 0066-4804

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Abstract

The pharmacokinetics of ceftizoxime (CZX) and of cefotaxime (CTX) were studied in five children and five adults after orthotopic liver transplantation (OLT). Delayed clearance of CZX (clearance of 0.21 to 1.26 ml/min per kg [body weight]) and CTX (clearance of 0.40 to 1.49 ml/min per kg) occurred in 7 of the 10 OLT patients. We conclude that abnormal CZX and CTX clearance is common after OLT and may be associated with minimal change in serum creatinine.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Burckart, GJ
Ptachcinski, RJ
Jones, DH
Howrie, DL
Venkataramanan, Rrv@pitt.eduRV
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: February 1987
Date Type: Publication
Journal or Publication Title: Antimicrob Agents Chemother
Volume: 31
Number: 2
Page Range: 323 - 324
DOI or Unique Handle: 10.1128/aac.31.2.323
Institution: University of Pittsburgh
Refereed: Yes
Uncontrolled Keywords: Adult, Cefotaxime, Ceftizoxime, Child, Preschool, Humans, Infant, Kinetics, Liver Transplantation, Middle Aged, Regression Analysis
ISSN: 0066-4804
Other ID: uls-drl:31735062118967, Starzl CV No. 702
Date Deposited: 08 Apr 2010 17:12
Last Modified: 05 Jun 2021 10:55
URI: http://d-scholarship.pitt.edu/id/eprint/4088

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