Markus, BH and Duquesnoy, RJ and Gordon, RD and Fung, JJ and Vanek, M and Klintmalm, G and Bryan, C and Van Thiel, D and Starzl, TE
(1988)
Histocompatibility and liver transplant outcome. Does HLA exert a dualistic effect?
Transplantation, 46 (3).
372 - 377.
ISSN 0041-1337
Abstract
An analysis of more than 500 liver transplants has demonstrated that HLA compatibility is associated with diminished allograft survival. Liver transplants with zero mismatches for class I and/or class II HLA antigens have shown significantly lower acturial survival rates than transplants with one or more mismatches for these loci. In a group of 199 failed liver allografts from patients undergoing retransplantation, a higher incidence of failure due to rejection correlated with a lower degree of HLA compatibility especially for HLA-DR. In contrast, the incidence of liver transplant failures due to primary nonfunction was relatively higher with HLA-DR compatible transplants. Considering the role of HLA as a restriction element in cellular interactions during the immune response, these findings suggest that HLA compatibility may have a dualistic effect on liver transplant outcome. On one hand, HLA compatibility reduced transplant rejection - and on the other hand, it may enhance other immunological mechanisms leading to allograft dysfunction, particularly in patients at risk of developing recurrent autoimmune diseases or infection.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
---|
Markus, BH | | | | Duquesnoy, RJ | | | | Gordon, RD | | | | Fung, JJ | | | | Vanek, M | | | | Klintmalm, G | | | | Bryan, C | | | | Van Thiel, D | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
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Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
Date: |
16 November 1988 |
Date Type: |
Publication |
Journal or Publication Title: |
Transplantation |
Volume: |
46 |
Number: |
3 |
Page Range: |
372 - 377 |
Institution: |
University of Pittsburgh |
Refereed: |
Yes |
ISSN: |
0041-1337 |
Other ID: |
uls-drl:31735062130368, Starzl CV No. 886 |
Date Deposited: |
08 Apr 2010 17:15 |
Last Modified: |
02 Feb 2019 13:58 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/4272 |
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