Ricordi, C and Tzakis, A and Alejandro, R and Zeng, Y and Demetris, AJ and Carroll, P and Fung, JJ and Mintz, DH and Starzl, TE
(1992)
Detection of intrahepatic human islets following combined liver-islet allotransplantation.
Pancreas, 7 (4).
507 - 509.
ISSN 0885-3177
Abstract
This article describes the localization of intact insulin-containing intrahepatic islets after combined liver-islet allotransplantation. The patient was a 36-year-old woman who underwent upper abdominal exenteration for neuroendocrine carcinoma; 289,000 islets were transplanted via portal vein infusion immediately after complete revascularization of the liver. Immunosuppression was with low-dose FK-506. OKT3 and steroids were used to treat one rejection episode 2 weeks after transplantation, but the patient subsequently developed multiple infections and died 109 days after transplantation. At autopsy, the transplanted liver did not show any sign of rejection and well-preserved islets were present in portal triads sampled from the anterior inferior edge of the right lobe. Immunohistochemical labeling confirmed the presence of insulin-containing cells. This finding indicated that human islets can survive after intrahepatic allotransplantation, despite positive cross-match with no HLA antigen match, suggesting that upper abdominal exenteration and liver transplantation may constitute a protective factor for the survival of allogeneic human islets. © 1992 Raven Press, Ltd., New York.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Ricordi, C | | | | | Tzakis, A | | | | | Alejandro, R | | | | | Zeng, Y | | | | | Demetris, AJ | | | | | Carroll, P | | | | | Fung, JJ | | | | | Mintz, DH | | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
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| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
1 January 1992 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Pancreas |
| Volume: |
7 |
| Number: |
4 |
| Page Range: |
507 - 509 |
| DOI or Unique Handle: |
10.1097/00006676-199207000-00014 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
0885-3177 |
| Other ID: |
uls-drl:31735062111616, Starzl CV No. 1373 |
| Date Deposited: |
08 Apr 2010 17:23 |
| Last Modified: |
27 Jan 2019 02:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/4759 |
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