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Islet cell allotransplantation in diabetic patients: Histologic findings in four adults simultaneously receiving kidney or liver transplants

Sever, CE and Demetris, AJ and Zeng, Y and Tzakis, A and Fung, JJ and Starzl, TE and Ricordi, C (1992) Islet cell allotransplantation in diabetic patients: Histologic findings in four adults simultaneously receiving kidney or liver transplants. American Journal of Pathology, 140 (5). 1255 - 1260. ISSN 0002-9440

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Abstract

Refined methods of islet cell purification have led to unprecedented success of islet cell allotransplantation via portal vein infusion in diabetic patients, resulting in marked reduction of exogenous insulin requirements and recently even insulin independence. The authors report the histologic findings of islet cell allografts in the liver of four patients who had undergone combined kidney-islet or liver-islet transplantation. Islet cell clusters were detected in subcapsular location at the edge of portal triads. The early post-transplant period was characterized by patchy mixed portal infiltrates. Only minimal inflammation but decreased islet cell granulation was observed in one patient 6 months after transplantation. As histologic detection of transplanted islet cells becomes available, additional parameters for evaluation of graft survival might be defined by morphologic assessment.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Sever, CE
Demetris, AJ
Zeng, Y
Tzakis, A
Fung, JJ
Starzl, TEtes11@pitt.eduTES11
Ricordi, C
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 1992
Date Type: Publication
Journal or Publication Title: American Journal of Pathology
Volume: 140
Number: 5
Page Range: 1255 - 1260
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0002-9440
Other ID: uls-drl:31735062112614, Starzl CV No. 1474
Date Deposited: 08 Apr 2010 17:25
Last Modified: 17 Nov 2019 02:55
URI: http://d-scholarship.pitt.edu/id/eprint/4860

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