Depression in Primary care: Interpersonal Counseling vs Selective serotonin reuptake inhibitors. The DEPICS Study. A multicenter randomized controlled trial. Rationale and design
Menchetti, M and Bortolotti, B and Rucci, P and Scocco, P and Bombi, A and Berardi, D and Affatati, V and Alberini, G and Baranzini, F and Bellino, S and Bellomo, A and Blasi, T and Bogetto, F and Bortolaso, P and Callegari, C and Carpiniello, B and Colombini, N and Contu, C and Croci, G and De Salvia, M and Diurni, M and Elisei, S and Ferretti, M and Fiore, P and Fusar-Poli, P and Iuso, S and Lacalamita, A and La Ferla, T and Lia, L and Luciano, CC and Magnani, M and Manganaro, D and Martinelli, V and Martino, I and Montaguti, MB and Nespeca, C and Petito, A and Pinna, F and Piselli, M and Politi, P and Quartesan, R and Rella, A and Restaino, F and Rigatelli, M and Sciarini, P and Simoni, E and Succui, M and Tedeschini, E and Todarello, O and Vender, S and Zaccagni, L and Zizza, M and Lullini, G and Pedrini, E and D'Onghia, A and Mazza, M and Papagni, S
(2010)
Depression in Primary care: Interpersonal Counseling vs Selective serotonin reuptake inhibitors. The DEPICS Study. A multicenter randomized controlled trial. Rationale and design.
BMC Psychiatry, 10.
Abstract
Background: Depression is a frequently observed and disabling condition in primary care, mainly treated by Primary Care Physicians with antidepressant drugs. Psychological interventions are recommended as first-line treatment by the most authoritative international guidelines but few evidences are available on their efficacy and effectiveness for mild depression.Methods/Design: This multi-center randomized controlled trial was conducted in 9 Italian centres with the aim to compare the efficacy of Inter-Personal Counseling, a brief structured psychological intervention, to that of Selective Serotonin Reuptake Inhibitors. Patients with depressive symptoms referred by Primary Care Physicians to psychiatric consultation-liaison services were eligible for the study if they met the DSM-IV criteria for major depression, had a score ≥13 on the 21-item Hamilton Depression Rating Scale, and were at their first or second depressive episode. The primary outcome was remission of depressive symptoms at 2-months, defined as a HDRS score ≤ 7. Secondary outcome measures were improvement in global functioning and recurrence of depressive symptoms at 12-months. Patients who did not respond to Inter-Personal Counseling or Selective Serotonin Reuptake Inhibitors at 2-months received augmentation with the other treatment.Discussion: This trial addresses some of the shortcomings of existing trials targeting major depression in primary care by evaluating the comparative efficacy of a brief psychological intervention that could be easily disseminated, by including a sample of patients with mild/moderate depression and by using different outcome measures. © 2010 Menchetti et al; licensee BioMed Central Ltd.
Share
Citation/Export: |
|
Social Networking: |
|
Details
Item Type: |
Article
|
Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
---|
Menchetti, M | | | | Bortolotti, B | | | | Rucci, P | | | | Scocco, P | | | | Bombi, A | | | | Berardi, D | | | | Affatati, V | | | | Alberini, G | | | | Baranzini, F | | | | Bellino, S | | | | Bellomo, A | | | | Blasi, T | | | | Bogetto, F | | | | Bortolaso, P | | | | Callegari, C | | | | Carpiniello, B | | | | Colombini, N | | | | Contu, C | | | | Croci, G | | | | De Salvia, M | | | | Diurni, M | | | | Elisei, S | | | | Ferretti, M | | | | Fiore, P | | | | Fusar-Poli, P | | | | Iuso, S | | | | Lacalamita, A | | | | La Ferla, T | | | | Lia, L | | | | Luciano, CC | | | | Magnani, M | | | | Manganaro, D | | | | Martinelli, V | | | | Martino, I | | | | Montaguti, MB | | | | Nespeca, C | | | | Petito, A | | | | Pinna, F | | | | Piselli, M | | | | Politi, P | | | | Quartesan, R | | | | Rella, A | | | | Restaino, F | | | | Rigatelli, M | | | | Sciarini, P | | | | Simoni, E | | | | Succui, M | | | | Tedeschini, E | | | | Todarello, O | | | | Vender, S | | | | Zaccagni, L | | | | Zizza, M | | | | Lullini, G | | | | Pedrini, E | | | | D'Onghia, A | | | | Mazza, M | | | | Papagni, S | | | |
|
Date: |
25 November 2010 |
Date Type: |
Publication |
Journal or Publication Title: |
BMC Psychiatry |
Volume: |
10 |
DOI or Unique Handle: |
10.1186/1471-244x-10-97 |
Schools and Programs: |
School of Medicine > Medicine School of Medicine > Psychiatry |
Refereed: |
Yes |
Date Deposited: |
16 Nov 2016 16:06 |
Last Modified: |
20 Dec 2018 00:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/30210 |
Metrics
Monthly Views for the past 3 years
Plum Analytics
Altmetric.com
Actions (login required)
 |
View Item |
|