Iasella, Carlo J
(2018)
A pharmacogenomic approach to antiplatelet therapy following percutaneous coronary intervention: a review.
Master Essay, University of Pittsburgh.
Abstract
Coronary artery disease is a substantial public health concern in the United States. Clopidogrel, an oral, antiplatelet medication, is a mainstay of medical therapy, but its activity is dependent on the CYP2C19 enzyme. Enzyme activity varies across the population based on variability in CYP2C19 alleles that can lead to loss of enzyme activity. Prasugrel and ticagrelor are newer alternatives to clopidogrel that avoid pharmacogenomic concerns but are more expensive and may be associated with more bleeding. This review aims to evaluate the existing literature surrounding the role of pharmacogenomics in the management of patients who require oral P2Y12 inhibitor therapy, discuss the implementation of clinical programs to promote a personalized medicine-based approach utilizing pharmacogenomics, and describe challenges and future directions for pharmacogenomics-based practice models.
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Details
| Item Type: |
Other Thesis, Dissertation, or Long Paper
(Master Essay)
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| Contributors: |
| Contribution | Contributors Name | Email | Pitt Username | ORCID  |
|---|
| Committee Chair | Finegold, David N. | dnf@pitt.edu | UNSPECIFIED | UNSPECIFIED | | Committee Member | Coons, James C. | jccoons@pitt.edu | UNSPECIFIED | UNSPECIFIED |
|
| Date: |
23 April 2018 |
| Date Type: |
Submission |
| Submission Date: |
30 March 2018 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
30 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
School of Public Health > Multidisciplinary MPH |
| Degree: |
MPH - Master of Public Health |
| Thesis Type: |
Master Essay |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
Pharmacogenomics
P2Y12
Clopidogrel
Percutaneous coronary intervention
Coronary artery disease |
| Date Deposited: |
31 May 2019 17:23 |
| Last Modified: |
31 May 2019 17:23 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/33992 |
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